Zijn de COVID-19 mutaties in Zuid Afrika en het Verenigd Koninkrijk hetzelfde ?
Op twitter kwam ik een aantal zeer informatieve draadjes tegen waarin diverse vragen over de recente mutaties van het COVID-19 virus worden beantwoord. In dit draadje de vraag of de mutaties in het Verenigd Koninkrijk en Zuid-Afrika dezelfde virusvariant opleveren?
Het draadje is gisteren gepubliceerd, Engelstalig en een beetje technisch maar goed te volgen.
Is the new UK variant the same as the new South African variant (501Y.V2)?
No.
They both share the same mutation in spike: N501Y (N->Y at position 501). However, the 2 variants have arisen separately.
1/Nhttps://t.co/m4sx1YN7dO pic.twitter.com/N1Zmyso4mh
— Dr Emma Hodcroft (@firefoxx66) December 19, 2020
S:N501Y has occurred multiple times around the world. Not all of these have risen & become prominent. So the role of 501Y is probably more complex.
UK variant & SA variant both have many other mutations that are being investigated.
3/N
— Dr Emma Hodcroft (@firefoxx66) December 19, 2020
Where have we seen these variants so far?
For the UK variant:
In the UK, we see sequences from England, Wales (a little hard to see) and Scotland. None in Northern Ireland so far.https://t.co/sdLXMBLlQ45/N pic.twitter.com/pIRhFsOuB6
— Dr Emma Hodcroft (@firefoxx66) December 19, 2020
For the SA variant:
So far, we only see this in South Africa.7/Nhttps://t.co/ytrwEBglML pic.twitter.com/ms2IeaUlbO
— Dr Emma Hodcroft (@firefoxx66) December 19, 2020
I'm re-running the cluster builds now with data from yesterday. I'll post a link when they are done, though I don't expect much will change from the above pictures/links.
9/N
— Dr Emma Hodcroft (@firefoxx66) December 19, 2020
Will it impact the vaccine? I don't think we know for sure yet. Hopefully not
The vaccine causes your body to recognise many parts of spike, so a few changes should not mean it stops working. However impact of more changes is less sure - scientists investigating this now.
11/N
— Dr Emma Hodcroft (@firefoxx66) December 19, 2020
Some vaccine information from @KrutikaKuppalli from the ACIP (Advisory Committee on Immunization Practices - advises the CDC in the USA).
— Dr Emma Hodcroft (@firefoxx66) December 19, 2020
A new run of the S:N501 data is up now - with improved background sequencing to better show how the mutations have arisen independently!
UK variant at top in green. SA variant the blue in the middle - stemming from "20C" label.
— Dr Emma Hodcroft (@firefoxx66) December 19, 2020
Zie ook:
COVID-19: Algeheel reisverbod Verenigd Koninkrijk
COVID-19: Nieuwe mutatie in Zuid-Afrika
Nieuwe Brits COVID-19 variant nu ook in Nederland, vliegverbod VK tot 1 januari
